CyClick Chemistry for the Synthesis of Cyclic Peptides.

Adebomi, V.*; Cohen, R. D.*; Wills, R.; Chavers, H. A. H.; Martin, G. E.; Raj, M. CyClick Chemistry for the Synthesis of Cyclic Peptides. Angew. Chem. Int. Ed. 2019, 58, 1907319080. *Equal contributions. Selected as Hot Paper for an upcoming issue of Angew. Chem. Int. Ed.; highlighted in ChemViews and SynPacts by Hisashi Yamamoto; F1000 prime Recommended.

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201911900

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Accurate de novo design of high-affinity protein-binding macrocycles using deep learning.

Rettie, S.*; Juergens, D.*; Adebomi, V.*; Lindenauer, K.; Gocke, G.; Palmer, J.; Baker, D.; Bhardwaj, G. Accurate de novo design of high-affinity protein-binding macrocycles using deep learning. Nat. Chem. Biol. 2025, 21, 1948–1956. *Equal contributions. Selected as the cover of Nat. Chem. Biol. (November 2025).

https://pubmed.ncbi.nlm.nih.gov/40542165/

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Metal-Free Selective Modification of Secondary Amides: Application in Late-Stage Diversification of Peptides.

Adebomi, V.; Sriram, M.; Streety, X.; Raj, M. Metal-free Selective Modification of Secondary Amides: Application in Late-Stage Diversification of Peptides. Org. Lett. 2021, 23, 6189-6193. Selected as the cover of Org. Lett. (August 2021).

https://pubs.acs.org/doi/10.1021/acs.orglett.1c01622

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A Tag-Free Platform for Synthesis and Screening of Cyclic Peptide Libraries.

Adebomi, V.*; Bruce, A.*; Czabala, P.; Palmer, J.; McFadden, W. M.; Lorson, Z. C.; Slack, R. L.; Bhardwaj, G.; Sarafianos, S. G.; Raj, M. A Tag-Free Cyclic Peptide Exploration Platform. Angew. Chem. Int. Ed. 2024, 63, e202320045. *Equal contributions.

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202320045

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Intramolecular Hydrogen Bonding Enables a Zwitterionic Mechanism for Macrocyclic Peptide Formation: Computational Mechanistic Studies of CyClick Chemistry.

Shao, H.; Adebomi, V.; Bruce, A.; Raj, M.; Houk, K. N. Intramolecular Hydrogen Bonding Enables a Zwitterionic Mechanism for Macrocyclic Peptide Formation: Computational Mechanistic Studies of CyClick Chemistry. Angew. Chem. Int. Ed. 2023, 62, e2023072.

Cyclic peptide structure prediction and design using AlphaFold.

Rettie, S. A.; Campbell, K. V.; Bera, A. K.; Kang, A.; Koslov, S.; De La Cruz, J.; Adebomi, V.; Zhou, G.; DiMaio, F.; Ovchinnikov, S.; Bhardwaj, G. Cyclic peptide structure prediction and design using AlphaFold. Nat. Comm. 2025, 16 (1), 4730.

Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy.

Wills, R.; Adebomi, V.; Spancake, C.; Cohen, R. D.; Raj, M. Synthesis of L-cyclic tetrapeptides by backbone amide activation CyClick strategy. Tetrahedron 2022, 126, 133071.

Selective Conversion of Unactivated C–N Amide Bond to C–C bond via Steric and Electronic Resonance Destabilization.

Adebomi, V.; Sriram, M.; Streety, X.; Raj, M. Selective Conversion of Unactivated C–N Amide Bond to C–C bond via Steric and Electronic Resonance Destabilization. Org. Lett. 2022, 24, 6525–6530.

Peptide cyclization at high concentration.

Wills, R.; Adebomi, V.; Raj, M. Peptide cyclization at high concentration. Synlett. 2020, 31, 1537-1542. (Invited Review article).

Site selective peptide macrocyclization.

Wills, R.; Adebomi, V.; Raj, M. Site selective peptide macrocyclization. ChemBioChem. 2020, doi.org/10.1002/cbic.202000398. (Invited Review article).

Bioinspired Nitroalkylation for Selective Peptide Modification and Peptide Stapling.

Sriram, M.; Adebomi, V.; Muneeswaran, Z. P.; Raj, M. Bioinspired Nitroalkylation for Selective Peptide Modification and Peptide Stapling. Angew. Chem. Int. Ed. 2019, 59, 2793-2801.